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1

Patient Outcomes After Decompression and Instrumented Posterior Spinal Fusion for Degenerative Spondylolisthesis

Nork, Sean E., Hu, Serena S., Workman, Kimberly L., Glazer, Paul A., Bradford, David S.

Journal:

Year:

1999

File:

PDF, 34.24 MB

1999

2

Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

Martin A. Graham, Suresh Senan, Hernani Robin Jr., Nils Eckhardt, Dennis Lendrem, Jeffery Hincks, Dennis Greenslade, Roy Rampling, Stanley B. Kaye, Reinhard von Roemeling, Paul Workman

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1997

Language:

english

File:

PDF, 193 KB

english, 1997

3

Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo

Ross J. Maxwell, Paul Workman, John R. Griffiths

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 491 KB

english, 1989

4

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

Martin G Rowlands, Yvette M Newbatt, Chrisostomos Prodromou, Laurence H Pearl, Paul Workman, Wynne Aherne

Journal:

Analytical Biochemistry

Year:

2004

Language:

english

File:

PDF, 417 KB

english, 2004

5

Combinatorial drug therapy for cancer in the post-genomic era

Al-Lazikani, Bissan, Banerji, Udai, Workman, Paul

Journal:

Nature Biotechnology

Year:

2012

Language:

english

File:

PDF, 2.20 MB

english, 2012

6

Gene expression microarray analysis in cancer biology, pharmacology, and drug development: progress and potential

Paul A. Clarke, Robert te Poele, Richard Wooster, Paul Workman

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 459 KB

english, 2001

7

Novel dynamic flow cytoenzymological determination of intracellular esterase inhibition by BCNU and related isocyanates

Caroline Dive, Paul Workman, James V. Watson

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 760 KB

english, 1987

8

Altered states: selectively drugging the Hsp90 cancer chaperone

Journal:

Trends in Molecular Medicine

Year:

2004

Language:

english

File:

PDF, 284 KB

english, 2004

9

Exploiting the Cancer Genome: Strategies for the Discovery and Clinical Development of Targeted Molecular Therapeutics

Yap, Timothy A., Workman, Paul

Journal:

Annual Review of Pharmacology

Year:

2012

Language:

english

File:

PDF, 680 KB

english, 2012

10

Inhibitors of the heat shock response: Biology and pharmacology

Marissa V. Powers, Paul Workman

Journal:

Year:

2007

Language:

english

File:

PDF, 647 KB

english, 2007

11

AHR- and DNA-Damage-Mediated Gene Expression Responses Induced by Benzo( a )pyrene in Human Cell Lines

Hockley, Sarah L., Arlt, Volker M., Brewer, Daniel, te Poele, Robert, Workman, Paul, Giddings, Ian, Phillips, David H.

Journal:

Chemical Research in Toxicology

Year:

2007

Language:

english

File:

PDF, 3.25 MB

english, 2007

12

Clinical Questions Raised by Clinicians at the Point of Care

Del Fiol, Guilherme, Workman, T. Elizabeth, Gorman, Paul N.

Journal:

JAMA Internal Medicine

Year:

2014

Language:

english

File:

PDF, 288 KB

english, 2014

13

Services provided by community pharmacies in Wayne County, Michigan: A comparison by ZIP code characteristics

Erickson, Steven R., Workman, Paul

Journal:

Journal of the American Pharmacists Association

Year:

2014

Language:

english

File:

PDF, 496 KB

english, 2014

14

Design and Development of Signal Transduction Inhibitors for Cancer Treatment: Experience and Challenges with Kinase Targets

Collins, Ian, Workman, Paul

Journal:

Current Signal Transduction Therapy

Year:

2006

Language:

english

File:

PDF, 317 KB

english, 2006

15

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

Workman, Paul, Draetta, Giulio F., Schellens, Jan H.M., Bernards, René

Journal:

Year:

2017

Language:

english

File:

PDF, 514 KB

english, 2017

16

Oncogenic RAC1 and NRAS drive resistance to endoplasmic reticulum stress through MEK/ERK signalling

Bright, Michael D., Clarke, Paul A., Workman, Paul, Davies, Faith E.

Journal:

Cellular Signalling

Year:

2018

Language:

english

File:

PDF, 6.73 MB

english, 2018

17

Inequality in Reading and Math Skills Forms Mainly before Kindergarten: A Replication, and Partial Correction, of “Are Schools the Great Equalizer?”

von Hippel, Paul T., Workman, Joseph, Downey, Douglas B.

Journal:

Sociology of Education

Year:

2018

Language:

english

File:

PDF, 1.00 MB

english, 2018

18

From patent to patient: analysing access to innovative cancer drugs

Sharpe, Eva, Hoey, Richard, Yap, Christina, Workman, Paul

Journal:

Drug Discovery Today

Year:

2020

Language:

english

File:

PDF, 395 KB

english, 2020

19

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

Frame, Sheelagh, Saladino, Chiara, MacKay, Craig, Atrash, Butrus, Sheldrake, Peter, McDonald, Edward, Clarke, Paul A., Workman, Paul, Blake, David, Zheleva, Daniella, Lampe, Jed N.

Journal:

Year:

2020

File:

PDF, 2.88 MB

2020

20

Targeting the Hsp90 Chaperone: Synthesis of Novel Resorcylic Acid Macrolactone Inhibitors of Hsp90

James E. H. Day, Swee Y. Sharp, Martin G. Rowlands, Wynne Aherne, Paul Workman, Christopher J. Moody

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 389 KB

english, 2010

21

Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies

Dr. James E. H. Day, Dr. Swee Y. Sharp, Dr. Martin G. Rowlands, Dr. Wynne Aherne, Dr. William Lewis, Dr. S. Mark Roe, Dr. Chrisostomos Prodromou, Prof. Dr. Laurence H. Pearl, Prof. Dr. Paul Workman, P

Journal:

Chemistry - A European Journal

Year:

2010

Language:

english

File:

PDF, 545 KB

english, 2010

22

Improved methodology for intracellular enzyme reaction and inhibition kinetics by flow cytometry

Dr. Caroline Dive, Paul Workman, James V. Watson

Journal:

Cytometry Part A

Year:

1987

Language:

english

File:

PDF, 896 KB

english, 1987

23

Multiparametric analysis of cell membrane permeability by two colour flow cytometry with complementary fluorescent probes

Caroline Dive, James V. Watson, Dr. Paul Workman

Journal:

Cytometry Part A

Year:

1990

Language:

english

File:

PDF, 791 KB

english, 1990

24

Unusually marked hypoxic sensitization to indoloquinone E09 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity

Jane A. Plumb, Paul Workman

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 685 KB

english, 1994

25

Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis

Ian M. Huxham, Andrew L. Barlow, Alex D. Lewis, Jane Plumb, Robert J. Mairs, Mark N. Gaze, Paul Workman

Journal:

International Journal of Cancer

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

26

Phospholipid antitumor agents

William J. Houlihan, Matthias Lohmeyer, Paul Workman, Seung H. Cheon

Journal:

Medicinal Research Reviews

Year:

1995

Language:

english

File:

PDF, 4.12 MB

english, 1995

27

Non-invasive MRS in new anticancer drug development

Paul Workman, Ross J. Maxwell, John R. Griffiths

Journal:

NMR in Biomedicine

Year:

1992

Language:

english

File:

PDF, 302 KB

english, 1992

28

The pharmacokinetics in mice and dogs of nitroimidazole radiosensitizers and chemosensitizers more lipophilic than misonidazole

Richard White, Paul Workman, Larry Owen

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1982

Language:

english

File:

PDF, 387 KB

english, 1982

29

The effect of radiosensitizer pretreatment on the response of the RIF-1 mouse sarcoma to cytotoxic drugs

Petter R. Twentyman, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1982

Language:

english

File:

PDF, 298 KB

english, 1982

30

Enhancement by electron-affinic agents of the therapeutic effects of cytotoxic agents against the KHT tumor: Structure-activity relationships

Paul Workman, Peter R. Twentyman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1982

Language:

english

File:

PDF, 390 KB

english, 1982

31

Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069

Paul Workman, Michael I. Walton

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1984

Language:

english

File:

PDF, 453 KB

english, 1984

32

Nitroimidazoles as modifiers of nitrosourea pharmacokinetics

Francis Y.F Lee, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1984

Language:

english

File:

PDF, 440 KB

english, 1984

33

Interaction of nitroimidazole sensitizers with drug metabolizing enzymes—Spectral and kinetic studies

Francis Y.F. Lee, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1986

Language:

english

File:

PDF, 668 KB

english, 1986

34

A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: Toxicity and pharmacokinetics

Hugh F.V. Newman, Norman M. Bleehen, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1986

Language:

english

File:

PDF, 535 KB

english, 1986

35

Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system

Davina J. Honess, Todd H. Wasserman, Paul Workman, Rose Ward, Norman M. Bleehen

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1988

Language:

english

File:

PDF, 693 KB

english, 1988

36

Micropharmacokinetics of chemical modifiers

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 1.13 MB

english, 1989

37

Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: A possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 404 KB

english, 1989

38

A multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

Norman M. Bleehen, Hugh F.V. Newman, Timothy S. Maughan, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1989

Language:

english

File:

PDF, 387 KB

english, 1989

39

Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (RO 03-8799) and etanidazole (SR 2508)

Timothy S. Maughan, Hugh F.V. Newman, Norman M. Bleehen, Rosemary Ward, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1990

Language:

english

File:

PDF, 688 KB

english, 1990

40

Editors' note

Todd H. Wasserman, Dietmar Siemann, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1992

Language:

english

File:

PDF, 53 KB

english, 1992

41

Relative importance of DT-diaphorase and hypoxia in the bioactivation of e09 by human lung tumor cell lines

Jane A. Plumb, Martijn Gerritsen, R. Milroy, Patricia Thomson, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1994

Language:

english

File:

PDF, 578 KB

english, 1994

42

Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors

Roy Rampling, Garth Cruickshank, Alexander D. Lewis, Sara A. Fitzsimmons, Paul Workman

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

1994

Language:

english

File:

PDF, 652 KB

english, 1994

43

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

Masahiko Hayakawa, Hiroyuki Kaizawa, Hiroyuki Moritomo, Tomonobu Koizumi, Takahide Ohishi, Minoru Okada, Mitsuaki Ohta, Shin-ichi Tsukamoto, Peter Parker, Paul Workman, Mike Waterfield

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 228 KB

english, 2006

44

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs)

Stephen Gorsuch, Vassilios Bavetsias, Martin G. Rowlands, G. Wynne Aherne, Paul Workman, Michael Jarman, Edward McDonald

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 237 KB

english, 2009

45

Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements

Jonathan M. Large, Jane E. Torr, Florence I. Raynaud, Paul A. Clarke, Angela Hayes, Francesca di Stefano, Frederique Urban, Stephen J. Shuttleworth, Nahid Saghir, Peter Sheldrake, Paul Workman, Edward

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 933 KB

english, 2011

46

4-Amino derivatives of the Hsp90 inhibitor CCT018159

Xavier Barril, Mandy C. Beswick, Adam Collier, Martin J. Drysdale, Brian W. Dymock, Alexandra Fink, Kate Grant, Robert Howes, Allan M. Jordan, Andrew Massey, Allan Surgenor, Joanne Wayne, Paul Workman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 257 KB

english, 2006

47

Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

Masahiko Hayakawa, Hiroyuki Kaizawa, Hiroyuki Moritomo, Tomonobu Koizumi, Takahide Ohishi, Mayumi Yamano, Minoru Okada, Mitsuaki Ohta, Shin-ichi Tsukamoto, Florence I. Raynaud, Paul Workman, Michael D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 160 KB

english, 2007

48

Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

Vassilios Bavetsias, Chongbo Sun, Nathalie Bouloc, Jóhannes Reynisson, Paul Workman, Spiros Linardopoulos, Edward McDonald

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 210 KB

english, 2007

49

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol

Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 788 KB

english, 2006

50

Probing the Probes: Fitness Factors For Small Molecule Tools

Paul Workman, Ian Collins

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.34 MB

english, 2010

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